Synthesis of 8, 5'-Anhydro-8-mercaptoadenosine

( 3 aR , 8 b 8 , 5 ' R ) 3 - [ ( 2 , 5 -

A robust synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin

The biosynthetic precursor of redox cofactor F420, 7,8-didemethyl-8-hydroxy-5-deazariboflavin, was prepared in four steps from 6-chlorouracil, 2-chloro-4-hydroxybenzaldehyde and bis-isopropylidene protected D-ribose. The latter aldehyde was transformed to the corresponding protected ribitylamine via the oxime, which was submitted to reduction with LiAlH4. Key advantage compared to previous synt...

Editorial 5..8

As this issue goes to print, our Journal of Town & City Management celebrates its first birthday. Since June 2010, not much has changed in the world . . . or has it? In our special editorial with views from JTCM’s Editorial Board on international trends in city management, few could have predicted quite what a test the European Union would face in terms of the credibility of its currency with t...

Bueter 5/8

Self-tolerance and tumor-induced peripheral tolerance may be responsible for the limitations of the immune system in controlling tumor growth in cancer patients. It is known, that self-proteins are continuously processed and presented by antigen presenting cells. During development, auto-reactive T cells encountering self peptide/self-MHC complexes are being eliminated in the thymus. This proce...

Synthesis of Methyl 8-Cyanoheptafulvene-8-carboxylate Derivatives

Heptafulvenes, fundamental members of non-alternant conjugated compounds, are known to be stabilized by introduction of electron-withdrawing substituents on the C-8 position, e.g., 8,8-dicyanoheptafulvene (1).i' The bond lengths of the exocyclic C=C of the heptafulvenes have frequently been discussed as a measure of the contribution of a dipolar form.') For example, the exocyclic C=C bond lengt...